AC-SDKP Dosing: What Research Data Show
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Calculate the AC-SDKP dose
The calculator is already set up for AC-SDKP — adjust the dose or diluent volume for your vial.
Human dosing
| Period / condition | Dose | Escalation |
|---|---|---|
| Start | 200–500 mcg per day, subcutaneous | Starting dose |
| Main regimen | 0.5–1 mg per day, subcutaneous | Increase if needed |
| Upper reference | up to ~2 mg per day | Maximum in this schedule |
Practical dosing and effect details
No controlled human data exist for AC-SDKP (goralatide), so the schedule here is extrapolated from preclinical and pharmacological sources. A structural study by Masuyer and colleagues (Scientific Reports, 2015) showed how angiotensin-converting enzyme (ACE) cleaves AC-SDKP at its N-domain, removing the terminal residue and rapidly inactivating the peptide in the bloodstream. That is one reason research protocols for AC-SDKP describe daily subcutaneous administration rather than infrequent high doses: a compound the body's own enzyme breaks down this quickly poorly sustains a stable level with sparse injections. The dose range on this page (200-500 mcg at the start, 0.5-1 mg in the main regimen, up to ~2 mg as an upper reference) reflects that same logic of frequent, moderate administration. This is reference information for planning a research protocol, not a medical recommendation and not instructions for self-administration.
How to reconstitute
An example reconstitution for convenient dosing. The exact ratios depend on your vial. For research reference only — not medical guidance.
- 1Add the diluentUse bacteriostatic water. Example: 2 ml into a 10 mg vial.AC-SDKP10 mg+ 2 mlDiluent
- 2Get the concentrationExample: 10 mg in 2 ml =AC-SDKP5 mg/ml(5,000 mcg/ml)
- 3Work out the volume per doseFor example, for a 0.2 mg dose:0.2 mg = 0.04 ml= 4 u. (U-100)
This is only an example calculation. You can use a different diluent volume — plug your own numbers into the calculator. Open calculator →
Research protocols
AC-SDKP: reference regimens
Controlled data on this compound are limited.
AC-SDKP (goralatide) is a tetrapeptide administered subcutaneously in studies.
AC-SDKP dosing in the sources gathered here is always given in micrograms or milligrams per day rather than per injection, so the starting and upper figures in the table should be read as a daily total, not a single-shot dose.
More scientific background in the AC-SDKP monograph
Notes and safety
- • AC-SDKP is a research peptide. Human safety and efficacy data are limited.
- • The regimens shown are based on publications and research protocols, not clinical recommendations.
- • Individual reactions may vary. Published protocols typically start dosing at the lower end of the reported range.
- • Not recommended for use with chronic illness, pregnancy, or breastfeeding.
- • This information is for educational purposes and is not medical advice.
AC-SDKP