AC-SDKP Dosing: What Research Data Show
> Updated:
Human schedule
Controlled data on this compound are limited. The regimens below were gathered from public sources online (studies and protocols) and are given as a reference, not a usage plan.
AC-SDKP (goralatide) is a tetrapeptide administered subcutaneously in studies. The figures below are a generalized reference extrapolated from preclinical (animal) work, not an established human protocol.
This is a concise reference to regimens described for adults; it is not an individual prescription.
AC-SDKP dosing in the sources gathered here is always given in micrograms or milligrams per day rather than per injection, so the starting and upper figures in the table should be read as a daily total, not a single-shot dose.
| Period / condition | Dose | Escalation |
|---|---|---|
| Start | 200–500 mcg per day, subcutaneous | Starting dose |
| Main regimen | 0.5–1 mg per day, subcutaneous | Increase if needed |
| Upper reference | up to ~2 mg per day | Maximum in this schedule |
Practical dosing and effect details
No controlled human data exist for AC-SDKP (goralatide), so the schedule here is extrapolated from preclinical and pharmacological sources. A structural study by Masuyer and colleagues (Scientific Reports, 2015) showed how angiotensin-converting enzyme (ACE) cleaves AC-SDKP at its N-domain, removing the terminal residue and rapidly inactivating the peptide in the bloodstream. That is one reason research protocols for AC-SDKP describe daily subcutaneous administration rather than infrequent high doses: a compound the body's own enzyme breaks down this quickly poorly sustains a stable level with sparse injections. The dose range on this page (200-500 mcg at the start, 0.5-1 mg in the main regimen, up to ~2 mg as an upper reference) reflects that same logic of frequent, moderate administration. This is reference information for planning a research protocol, not a medical recommendation and not instructions for self-administration.
This reference is research-use material. The information is not medical advice and is not intended for diagnosis, treatment or prevention of disease.