Retatrutide (LY3437943) is a synthetic single-molecule triple agonist of the GIP, GLP-1 and glucagon receptors studied in metabolic research on obesity and type 2 diabetes.

5-Amino-1MQ (5-amino-1-methylquinolinium) is a membrane-permeable small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that consumes S-adenosylmethionine and nicotinamide. The compound is studied as a research tool for probing NAD+ metabolism, methylation flux and adipocyte biology in preclinical models. For research use only (RUO).

ACE-083 is Acceleron's follistatin-Fc fusion protein, engineered to act only in the muscle it is injected into. In phase 2 trials in FSHD and CMT it reliably increased muscle volume but did not improve function, and development was discontinued in 2020.