IGF-1 LR3: dosing evidence
> Updated:
Calculate the IGF-1 LR3 dose
The calculator is already set up for IGF-1 LR3 — adjust the dose or diluent volume for your vial.
Human dosing
IGF-1 LR3 dosing in the protocols on record mostly falls within 20–100 mcg per day: the breakdown by period follows below.
| Period / condition | Dose | Escalation |
|---|---|---|
| Start | 20 mcg once daily, subcutaneous | Starting dose |
| Typical regimen | 20–50 mcg once daily | Increase if needed |
| Upper range | up to 100 mcg/day; ~4–6 week cycle, then off | Maximum in this schedule |
Background on the molecule, its mechanism and primary sources is covered in the monograph.
Practical dosing and effect details
IGF-1 LR3 is not native human IGF-1: it is an engineered analog with 13 extra amino acids added at the N-terminus and a glutamate-to-arginine substitution at position 3. Francis and colleagues (Journal of Molecular Endocrinology, 1992) showed that this analog binds IGF-binding proteins (IGFBPs) far more weakly than native IGF-1. Those proteins normally keep most circulating IGF-1 inactive; an analog that mostly escapes that binding is more potent than native IGF-1 in cell culture and in rat experiments. These results cannot be converted into a human dose: the figures in the table above come from community protocols.
The daily small subcutaneous doses also come from those protocols, not from human studies. The upper range on this page (a 4 to 6 week cycle, then a break) is usually linked to caution around continuous, unbroken stimulation of a growth-factor receptor.
This is reference information for planning a research protocol, not a medical recommendation and not instructions for self-administration.
How to reconstitute
An example reconstitution for convenient dosing. The exact ratios depend on your vial. For research reference only — not medical guidance.
- 1Add the diluentUse bacteriostatic water. Example: 2 ml into a 1 mg vial.IGF-1 LR31 mg+ 2 mlDiluent
- 2Get the concentrationExample: 1 mg in 2 ml =IGF-1 LR30.5 mg/ml(500 mcg/ml)
- 3Work out the volume per doseFor example, for a 0.02 mg dose:0.02 mg = 0.04 ml= 4 u. (U-100)
This is only an example calculation. You can use a different diluent volume — plug your own numbers into the calculator. Open calculator →
Research protocols
IGF-1 LR3: reference regimens
There are no controlled human trials of this compound.
IGF-1 LR3 is described in available materials as a once-daily subcutaneous injection.
More scientific background in the IGF-1 LR3 monograph
Notes and safety
- • IGF-1 LR3 is a research peptide. Human safety and efficacy data are limited.
- • The regimens shown are based on publications and research protocols, not clinical recommendations.
- • Individual reactions may vary. Published protocols typically start dosing at the lower end of the reported range.
- • Not recommended for use with chronic illness, pregnancy, or breastfeeding.
- • This information is for educational purposes and is not medical advice.
IGF-1 LR3