SS-31 / elamipretide dosing schedule
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Calculate the SS-31 dose
The calculator is already set up for SS-31 — adjust the dose or diluent volume for your vial.
Human dosing
SS-31 (elamipretide) dosage differs noticeably between clinical trials and research-protocol summaries, so the clinical reference and the research range are shown separately below.
| Period / condition | Dose | Escalation |
|---|---|---|
| Start | 2–5 mg subcutaneously, once daily | Starting dose |
| Standard range | 5–10 mg subcutaneously, once daily | Increase if needed |
| Upper protocol range | 10–20 mg subcutaneously, once daily | Maximum in this schedule |
| Clinical trials | 40 mg subcutaneously, once daily | Reference from trials |
Practical dosing and effect details
The 'clinical trials, 40 mg' row in the table above is not a rough estimate, it comes from an actual protocol. In Thompson and colleagues' study (Genetics in Medicine, 2021), known as TAZPOWER, patients with Barth syndrome first received subcutaneous elamipretide at 40 mg per day or placebo for 12 weeks in a crossover design with a washout pause between arms, purely for trial control. Participants then moved to continuous daily 40 mg dosing with no further pauses; over 168 weeks of that extension, they walked on average 96 meters further on the 6-minute walk test versus baseline.
It was the long continuous phase, not the initial short one, that produced the measurable result: by the researchers' design, the peptide's mitochondrial effect depends on a steady daily presence of the compound in the body rather than on a single concentration peak.
This is reference information from a published trial, not a medical recommendation and not instructions for self-administration.
How to reconstitute
An example reconstitution for convenient dosing. The exact ratios depend on your vial. For research reference only — not medical guidance.
- 1Add the diluentUse bacteriostatic water. Example: 2 ml into a 10 mg vial.SS-3110 mg+ 2 mlDiluent
- 2Get the concentrationExample: 10 mg in 2 ml =SS-315 mg/ml(5,000 mcg/ml)
- 3Work out the volume per doseFor example, for a 5 mg dose:5 mg = 1 ml= 100 u. (U-100)
This is only an example calculation. You can use a different diluent volume — plug your own numbers into the calculator. Open calculator →
Research protocols
SS-31: reference regimens
SS-31 (elamipretide) is given by subcutaneous injection once daily after reconstitution.
More scientific background in the SS-31 monograph
Notes and safety
- • SS-31 is a research peptide. Human safety and efficacy data are limited.
- • The regimens shown are based on publications and research protocols, not clinical recommendations.
- • Individual reactions may vary. Published protocols typically start dosing at the lower end of the reported range.
- • Not recommended for use with chronic illness, pregnancy, or breastfeeding.
- • This information is for educational purposes and is not medical advice.
SS-31