RESEARCH USE ONLY
#антифіброз
Monographs tagged “антифіброз”.
Anti-fibrosisAc-SDKP (goralatide): endogenous tetrapeptide and ACE N-domain substrateAc-SDKP is the N-terminal fragment of thymosin β4 and the only natural specific substrate of the ACE N-domain. Its receptor has never been identified, and its clinical history ran backwards: as goralatide it reached phase I–II for chemoprotection in the 1990s, while the antifibrotic indication it is known for today has never been tested in humans.Tissue repairBMP-7 (OP-1): a TGF-β family growth factor and the endogenous brake on TGF-β1BMP-7, or OP-1, is a recombinant TGF-β family growth factor, not a short synthetic peptide. It is the only molecule in this group that reached the operating room: as OP-1 it held FDA authorisation under a humanitarian device exemption before leaving the US market in 2014. This monograph covers why BMP-7 is better described as a brake on TGF-β1 than a repair signal, what the kidney models showed, endogenous antagonists, the carrier problem, the negative THR-184 phase 2, and what to check in an analytical package. RUO.Healing and regenerationHGF (Hepatocyte Growth Factor): c-Met ligand, regeneration and anti-fibrosisHGF is not a peptide but a ~90 kDa two-chain glycoprotein related to plasminogen, carrying a catalytically dead protease domain. It is the sole ligand of the c-Met proto-oncogene. This monograph covers structure, its threefold discovery, knockout and liver-regeneration evidence, the failed phase 3 of VM202 gene therapy, and open questions. RUO.