RESEARCH USE ONLY
#мітохондрії
Monographs tagged “мітохондрії”.
ERR agonistsSLU-PP-332 — synthetic pan-ERR agonist (exercise mimetic)SLU-PP-332 is a synthetic small-molecule pan-ERR agonist (ERRα/β/γ) that, in rodents, reproduces part of the metabolic response to aerobic exercise (an «exercise mimetic»). It is a small molecule, not a peptide, and has no established human dose. This is a scientific reference summary for research-use-only (RUO) material.ERR agonistsSLU-PP-915 — an orally bioavailable, boronic-acid pan-ERR agonistSLU-PP-915 is a boronic-acid small molecule and pan-ERRα/β/γ agonist from Saint Louis University. Unlike the acylhydrazone SLU-PP-332, it was engineered for metabolic stability — and became the first orally bioavailable member of the series. The entire evidence base is cells and mice; there are no human studies.Mitochondrial & Longevity PeptidesSS-31 (Elamipretide): Mitochondria-Targeting TetrapeptideSS-31 (elamipretide, the Szeto–Schiller peptide) is an aromatic-cationic tetrapeptide, H-D-Arg-Dmt-Lys-Phe-NH₂, that selectively binds cardiolipin in the inner mitochondrial membrane. This monograph reviews its structure, molecular mechanism, preclinical and clinical research record, pharmacokinetics and analytics. For research use only (RUO).NAD+ / metabolic longevityNicotinamide Riboside (NR)Nicotinamide riboside is the riboside form of vitamin B3 and an NAD⁺ precursor with its own enzymatic route (NRK1/NRK2), described only in 2004. Mechanism, the 2025 enterohepatic-circulation finding, the NR-versus-NMN argument, and the central fact of the clinical record: NAD⁺ rises reliably, functional outcomes mostly do not. Research reagent (RUO).