RESEARCH USE ONLY
#AMPK
Monographs tagged “AMPK”.
Mitochondrial & Longevity PeptidesMOTS-c (mitochondrial-derived peptide)MOTS-c is a 16-amino-acid peptide encoded within an alternative reading frame of the 12S rRNA gene (MT-RNR1) of mitochondrial DNA. It activates AMPK, translocates to the nucleus under metabolic stress and regulates adaptive gene expression; in preclinical models it modulates glucose and lipid homeostasis. The material is for laboratory research use only (RUO).Metabolic peptidesPXL770 — direct AMPK activator (a small molecule, not a peptide)PXL770 is a synthetic small molecule (a thienopyridone derivative) from Poxel SA, a first-in-class direct allosteric AMPK activator. Target engagement was confirmed in humans in phase 1b, but the phase 2a STAMP-NAFLD trial missed its primary endpoint; the programme was redirected to ADPKD and X-ALD, where the data remain preclinical.