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#GDF11

Monographs tagged “GDF11”.

Muscle growthACE-083: a locally acting follistatin-Fc ActRII ligand trapACE-083 is Acceleron's follistatin-Fc fusion protein, engineered to act only in the muscle it is injected into. In phase 2 trials in FSHD and CMT it reliably increased muscle volume but did not improve function, and development was discontinued in 2020.