RESEARCH USE ONLY
#MDP
Monographs tagged “MDP”.
Mitochondrial & Longevity PeptidesMOTS-c (mitochondrial-derived peptide)MOTS-c is a 16-amino-acid peptide encoded within an alternative reading frame of the 12S rRNA gene (MT-RNR1) of mitochondrial DNA. It activates AMPK, translocates to the nucleus under metabolic stress and regulates adaptive gene expression; in preclinical models it modulates glucose and lipid homeostasis. The material is for laboratory research use only (RUO).MitochondriaHumanin — a mitochondrial-derived peptide (MDP)Humanin is a 24-amino-acid mitochondrial-derived peptide (MDP) encoded within the 16S rRNA region of mitochondrial DNA (MT-RNR2). It was the first MDP identified; it is studied as a cytoprotective, anti-apoptotic signal in neuroprotection and metabolic ageing. This reference summarises the chemistry, mechanism and published preclinical record; research use only (RUO), with no established human dose.