RESEARCH USE ONLY
#RUO
Monographs tagged “RUO”.
Mitochondrial & Longevity Peptides5-Amino-1MQ (NNMT inhibitor)5-Amino-1MQ (5-amino-1-methylquinolinium) is a membrane-permeable small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that consumes S-adenosylmethionine and nicotinamide. The compound is studied as a research tool for probing NAD+ metabolism, methylation flux and adipocyte biology in preclinical models. For research use only (RUO).Repair & Recovery PeptidesARA-290 (cibinetide): an EPO-derived peptide agonist of the innate repair receptorARA-290 (cibinetide) is a synthetic 11-mer peptide reproducing the aqueous face of erythropoietin helix B that selectively activates the innate repair receptor (the EPOR/βcR heterocomplex) without driving erythropoiesis. This monograph covers structure, molecular mechanism, signaling, the preclinical and clinical research record, pharmacokinetics and analytics. Research-use-only content.Anti-fibrosisB7-33: a single-chain relaxin B-chain analog and functionally selective RXFP1 agonistB7-33 is a synthetic single-chain peptide derived from the relaxin-2 B-chain and the first functionally selective (biased) agonist of RXFP1, with anti-fibrotic activity in preclinical heart, lung and kidney models. This material is a scientific reference only (RUO); no established human dose exists.Tissue repairBMP-7 (OP-1): a TGF-β family growth factor and the endogenous brake on TGF-β1BMP-7, or OP-1, is a recombinant TGF-β family growth factor, not a short synthetic peptide. It is the only molecule in this group that reached the operating room: as OP-1 it held FDA authorisation under a humanitarian device exemption before leaving the US market in 2014. This monograph covers why BMP-7 is better described as a brake on TGF-β1 than a repair signal, what the kidney models showed, endogenous antagonists, the carrier problem, the negative THR-184 phase 2, and what to check in an analytical package. RUO.Anti-agingFOXO4-DRI: a senolytic peptide that disrupts the FOXO4-p53 interactionFOXO4-DRI is a synthetic senolytic peptide on a D-retro-inverso scaffold that disrupts the FOXO4-p53 interaction and selectively triggers apoptosis in senescent cells. This monograph summarises its design, mechanism, preclinical research record (in vivo in mice and in vitro in human cells) and the maturity of the evidence base. The material is a scientific reference only (RUO); no established human dose exists.Healing and regenerationHGF (Hepatocyte Growth Factor): c-Met ligand, regeneration and anti-fibrosisHGF is not a peptide but a ~90 kDa two-chain glycoprotein related to plasminogen, carrying a catalytically dead protease domain. It is the sole ligand of the c-Met proto-oncogene. This monograph covers structure, its threefold discovery, knockout and liver-regeneration evidence, the failed phase 3 of VM202 gene therapy, and open questions. RUO.Mitochondrial & Longevity PeptidesMOTS-c (mitochondrial-derived peptide)MOTS-c is a 16-amino-acid peptide encoded within an alternative reading frame of the 12S rRNA gene (MT-RNR1) of mitochondrial DNA. It activates AMPK, translocates to the nucleus under metabolic stress and regulates adaptive gene expression; in preclinical models it modulates glucose and lipid homeostasis. The material is for laboratory research use only (RUO).Anti-agingP021 (P21): a CNTF-derived neurotrophic peptidergic compoundP021 (Ac-DGGL(A)G-NH₂) is a synthetic small neurotrophic compound derived from the active region of ciliary neurotrophic factor (CNTF). In rodent Alzheimer's and ageing models it enhances hippocampal neurogenesis and BDNF and reduces tau hyperphosphorylation. The evidence base is entirely preclinical; no human dose is established. Reference material only (RUO).Metabolic peptidesPXL770 — direct AMPK activator (a small molecule, not a peptide)PXL770 is a synthetic small molecule (a thienopyridone derivative) from Poxel SA, a first-in-class direct allosteric AMPK activator. Target engagement was confirmed in humans in phase 1b, but the phase 2a STAMP-NAFLD trial missed its primary endpoint; the programme was redirected to ADPKD and X-ALD, where the data remain preclinical.ERR agonistsSLU-PP-332 — synthetic pan-ERR agonist (exercise mimetic)SLU-PP-332 is a synthetic small-molecule pan-ERR agonist (ERRα/β/γ) that, in rodents, reproduces part of the metabolic response to aerobic exercise (an «exercise mimetic»). It is a small molecule, not a peptide, and has no established human dose. This is a scientific reference summary for research-use-only (RUO) material.ERR agonistsSLU-PP-915 — an orally bioavailable, boronic-acid pan-ERR agonistSLU-PP-915 is a boronic-acid small molecule and pan-ERRα/β/γ agonist from Saint Louis University. Unlike the acylhydrazone SLU-PP-332, it was engineered for metabolic stability — and became the first orally bioavailable member of the series. The entire evidence base is cells and mice; there are no human studies.Mitochondrial & Longevity PeptidesSS-31 (Elamipretide): Mitochondria-Targeting TetrapeptideSS-31 (elamipretide, the Szeto–Schiller peptide) is an aromatic-cationic tetrapeptide, H-D-Arg-Dmt-Lys-Phe-NH₂, that selectively binds cardiolipin in the inner mitochondrial membrane. This monograph reviews its structure, molecular mechanism, preclinical and clinical research record, pharmacokinetics and analytics. For research use only (RUO).Ancillary SuppliesBacteriostatic Water for InjectionSterile Water for Injection with 0.9% benzyl alcohol as a bacteriostatic preservative — the standard multi-dose diluent for reconstituting lyophilized research peptides. Composition, preservative chemistry, difference from sterile water, concentration math, stability and storage. Research-use-only (RUO) reagent.Bioregulators & AntioxidantsPinealon (Glu-Asp-Arg, EDR) — a Khavinson short peptidePinealon is a synthetic Glu-Asp-Arg (EDR) tripeptide from the Khavinson family of short peptides, studied as a neurotropic bioregulator. In preclinical models EDR penetrates the cell nucleus, interacts site-specifically with double-stranded DNA and modulates gene expression while lowering reactive oxygen species. This monograph summarizes its chemistry, molecular mechanism and the published research record; for research use only (RUO).