RESEARCH USE ONLY
#TGF-β1
Monographs tagged “TGF-β1”.
Anti-fibrosisAc-SDKP (goralatide): endogenous tetrapeptide and ACE N-domain substrateAc-SDKP is the N-terminal fragment of thymosin β4 and the only natural specific substrate of the ACE N-domain. Its receptor has never been identified, and its clinical history ran backwards: as goralatide it reached phase I–II for chemoprotection in the 1990s, while the antifibrotic indication it is known for today has never been tested in humans.Tissue repairBMP-7 (OP-1): a TGF-β family growth factor and the endogenous brake on TGF-β1BMP-7, or OP-1, is a recombinant TGF-β family growth factor, not a short synthetic peptide. It is the only molecule in this group that reached the operating room: as OP-1 it held FDA authorisation under a humanitarian device exemption before leaving the US market in 2014. This monograph covers why BMP-7 is better described as a brake on TGF-β1 than a repair signal, what the kidney models showed, endogenous antagonists, the carrier problem, the negative THR-184 phase 2, and what to check in an analytical package. RUO.