RESEARCH USE ONLY
Mitochondrial Longevity
This topic hub explores compounds associated with mitochondrial function and longevity. It includes research reagents such as 5-Amino-1MQ, a NNMT inhibitor; MOTS-c, a mitochondria-derived peptide; NAD⁺, a vital coenzyme; and SS-31, a mitochondria-targeted tetrapeptide. Readers can find detailed monographs discussing their mechanisms, purity, and the published research supporting their study.
In this topic
Mitochondrial & Longevity Peptides5-Amino-1MQ (NNMT inhibitor)5-Amino-1MQ (5-amino-1-methylquinolinium) is a membrane-permeable small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that consumes S-adenosylmethionine and nicotinamide. The compound is studied as a research tool for probing NAD+ metabolism, methylation flux and adipocyte biology in preclinical models. For research use only (RUO).Mitochondrial & Longevity PeptidesMOTS-c (mitochondrial-derived peptide)MOTS-c is a 16-amino-acid peptide encoded within an alternative reading frame of the 12S rRNA gene (MT-RNR1) of mitochondrial DNA. It activates AMPK, translocates to the nucleus under metabolic stress and regulates adaptive gene expression; in preclinical models it modulates glucose and lipid homeostasis. The material is for laboratory research use only (RUO).Mitochondrial & Longevity PeptidesNAD⁺ (Nicotinamide Adenine Dinucleotide)NAD⁺ is the central redox coenzyme and, at the same time, a substrate for sirtuins, PARPs and CD38. An overview of its structure, biosynthesis (de novo, Preiss–Handler, salvage), redox chemistry, consuming enzymes and role in ageing biology. Research-use-only (RUO) reagent.Mitochondrial & Longevity PeptidesSS-31 (Elamipretide): Mitochondria-Targeting TetrapeptideSS-31 (elamipretide, the Szeto–Schiller peptide) is an aromatic-cationic tetrapeptide, H-D-Arg-Dmt-Lys-Phe-NH₂, that selectively binds cardiolipin in the inner mitochondrial membrane. This monograph reviews its structure, molecular mechanism, preclinical and clinical research record, pharmacokinetics and analytics. For research use only (RUO).