B7-33 dosing
> Updated:
Human schedule
Controlled data on this compound are limited. The regimens below were gathered from public sources online (studies and protocols) and are given as a reference, not a usage plan.
B7-33 is a relaxin analogue administered by subcutaneous injection in research. The values below are a generalized reference from preclinical data and protocols (no validated human regimens exist).
This is a concise reference to regimens described for adults; it is not an individual prescription.
B7-33 dosing in the sources gathered here is measured in micrograms rather than milligrams: the typical 100-250 mcg per day range is an order of magnitude below most other peptides on this site.
| Period / condition | Dose | Escalation |
|---|---|---|
| Start (week 1) | 100 mcg, once daily | Starting dose |
| Maintenance | 100–250 mcg, once daily | Increase if needed |
| Maximum in schedule | 250 mcg, once daily | Maximum in this schedule |
| Cycle length | 4–8 weeks | , |
Practical dosing and effect details
In a study by Devarakonda and colleagues (Journal of the American Heart Association, 2020), mice received a single 0.25 mg/kg intraperitoneal dose of B7-33 five minutes before blood flow was restored after myocardial ischemia. At 24 hours, fractional shortening in the treated animals was 29.57±1.74% versus 23.34±1.84% in controls, meaning cardiac function was better preserved after one well-timed dose. The dose was chosen to be equimolar to the relaxin dose used in an earlier study from the same group (Hossain and colleagues, Chemical Science, 2016), which first described B7-33 as a selective RXFP1 agonist. This is a single acute dose in a mouse model, not a daily human schedule; the results do not prove an effect in humans and do not match the doses in the table on this page, which is extrapolated from other sources. This is reference information for planning a research protocol, not a medical recommendation and not instructions for self-administration.
This reference is research-use material. The information is not medical advice and is not intended for diagnosis, treatment or prevention of disease.