B7-33 dosing
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Calculate the B7-33 dose
The calculator is already set up for B7-33 — adjust the dose or diluent volume for your vial.
Human dosing
B7-33 dosing in the sources gathered here is measured in micrograms rather than milligrams: the typical 100-250 mcg per day range is an order of magnitude below most other peptides on this site.
| Period / condition | Dose | Escalation |
|---|---|---|
| Start (week 1) | 100 mcg, once daily | Starting dose |
| Maintenance | 100–250 mcg, once daily | Increase if needed |
| Maximum in schedule | 250 mcg, once daily | Maximum in this schedule |
| Cycle length | 4–8 weeks | , |
Practical dosing and effect details
In a study by Devarakonda and colleagues (Journal of the American Heart Association, 2020), mice received a single 0.25 mg/kg intraperitoneal dose of B7-33 five minutes before blood flow was restored after myocardial ischemia. At 24 hours, fractional shortening in the treated animals was 29.57±1.74% versus 23.34±1.84% in controls, meaning cardiac function was better preserved after one well-timed dose. The dose was chosen to be equimolar to the relaxin dose used in an earlier study from the same group (Hossain and colleagues, Chemical Science, 2016), which first described B7-33 as a selective RXFP1 agonist. This is a single acute dose in a mouse model, not a daily human schedule; the results do not prove an effect in humans and do not match the doses in the table on this page, which is extrapolated from other sources. This is reference information for planning a research protocol, not a medical recommendation and not instructions for self-administration.
How to reconstitute
An example reconstitution for convenient dosing. The exact ratios depend on your vial. For research reference only — not medical guidance.
- 1Add the diluentUse bacteriostatic water. Example: 2 ml into a 10 mg vial.B7-3310 mg+ 2 mlDiluent
- 2Get the concentrationExample: 10 mg in 2 ml =B7-335 mg/ml(5,000 mcg/ml)
- 3Work out the volume per doseFor example, for a 0.1 mg dose:0.1 mg = 0.02 ml= 2 u. (U-100)
This is only an example calculation. You can use a different diluent volume — plug your own numbers into the calculator. Open calculator →
Research protocols
B7-33: reference regimens
Controlled data on this compound are limited.
B7-33 is a relaxin analogue administered by subcutaneous injection in research.
More scientific background in the B7-33 monograph
Notes and safety
- • B7-33 is a research peptide. Human safety and efficacy data are limited.
- • The regimens shown are based on publications and research protocols, not clinical recommendations.
- • Individual reactions may vary. Published protocols typically start dosing at the lower end of the reported range.
- • Not recommended for use with chronic illness, pregnancy, or breastfeeding.
- • This information is for educational purposes and is not medical advice.
B7-33