Epithalamin: dosing schedule
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Calculate the Epithalamin dose
The calculator is already set up for Epithalamin — adjust the dose or diluent volume for your vial.
Human dosing
| Period / condition | Dose | Escalation |
|---|---|---|
| Base course (10 days) | 10 mg/day IM | Starting dose |
| Extended course (up to 20 days) | 5 mg/day IM | Increase if needed |
| Course repetition | same course 2–3x per year | Maximum in this schedule |
Practical dosing and effect details
Epithalamin, a pineal polypeptide complex, is used in studies as courses of intramuscular injections rather than continuously. In a study by Korkushko, Khavinson, Shatilo, and Magdich (Bulletin of Experimental Biology and Medicine, 2004), course-based epithalamin administration in elderly subjects normalized the pineal gland's daily melatonin rhythm, raising its nighttime level specifically in those whose pineal function had been reduced.
That matches the course logic on this page: a base 10-day course and an extended 20-day variant, repeated 2-3 times a year, rather than continuous administration. The cited study does not report an exact dose figure; the schedule above is a generalized reference drawn from published protocols, not a reproduction of the specific dosing used in that study.
This is reference information for planning a research protocol, not a medical recommendation and not instructions for self-administration.
How to reconstitute
An example reconstitution for convenient dosing. The exact ratios depend on your vial. For research reference only — not medical guidance.
- 1Add the diluentUse bacteriostatic water. Example: 2 ml into a 10 mg vial.Epithalamin10 mg+ 2 mlDiluent
- 2Get the concentrationExample: 10 mg in 2 ml =Epithalamin5 mg/ml(5,000 mcg/ml)
- 3Work out the volume per doseFor example, for a 5 mg dose:5 mg = 1 ml= 100 u. (U-100)
This is only an example calculation. You can use a different diluent volume — plug your own numbers into the calculator. Open calculator →
Research protocols
Epithalamin: reference regimens
Epithalamin is a pineal polypeptide preparation that studies administered by intramuscular (less often subcutaneous) injection in short courses.
Epithalamin dosing instructions in research sources always describe a course, not a one-off injection: the course format holds the same shape in both the base 10-day and the extended 20-day variant on this page.
More scientific background in the Epithalamin monograph
Notes and safety
- • Epithalamin is a research peptide. Human safety and efficacy data are limited.
- • The regimens shown are based on publications and research protocols, not clinical recommendations.
- • Individual reactions may vary. Published protocols typically start dosing at the lower end of the reported range.
- • Not recommended for use with chronic illness, pregnancy, or breastfeeding.
- • This information is for educational purposes and is not medical advice.
Epithalamin