MIF-1: dosing and reconstitution
> Updated:
Human schedule
MIF-1 (Pro-Leu-Gly-NH2) was given by subcutaneous injection in the available studies. The figures below are a generalized reference from published pilot protocols, not an instruction.
This is a concise reference to regimens described for adults; it is not an individual prescription.
MIF-1 dosing in pilot protocols does not scale up in a straight line: 10 mg subcutaneously daily in short cycles produces a different effect profile than the much higher oral doses that some reports found weaker than the lower dose.
| Period / condition | Dose | Escalation |
|---|---|---|
| Base cycle (day 1–5) | 10 mg subcutaneously, once daily, 5 consecutive days | Starting dose |
| Repeat cycle | 10 mg/day × 5 days after a 2-day to 1–2-week washout | , |
| Higher doses | 75 mg/day orally in some reports gave a weaker effect than the low dose | Maximum in this schedule (inverted-U curve) |
Practical dosing and effect details
Pilot studies of MIF-1 (Pro-Leu-Gly-NH2) show a pattern pharmacologists call an inverted-U dose-response curve: the effect increases with dose only up to a point, and beyond that point a higher dose weakens the result rather than strengthening it. That is exactly what the table above shows: 75 mg taken orally gave a weaker result in some reports than a much lower dose. A non-monotonic dose response like this is not unusual in peptide pharmacology, though the specific mechanism for MIF-1 itself has not been established. That is why the schedule on this page does not follow a more-is-better logic: the base subcutaneous cycle (10 mg daily for 5 consecutive days) was set for a specific experiment, and the repeat cycle after a 2-day to 2-week washout follows the same approach: a short administration window with a break, not a continuous dose increase. This is reference information for planning a research protocol, not a medical recommendation and not instructions for self-administration.
This reference is research-use material. The information is not medical advice and is not intended for diagnosis, treatment or prevention of disease.