BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide whose sequence reproduces a fragment of a protective human gastric juice protein. Preclinical research uses it as a stable model compound for studying cytoprotection and connective-tissue regeneration. This page collects the chemistry of the molecule and the main directions of its study. It is reference material about a research reagent, not medical advice.

Chemistry and structure

The molecule is built from 15 amino-acid residues: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val. Molecular formula C62H98N16O22, molar mass about 1419.5 g/mol, CAS (Chemical Abstracts Service number) number 137525-51-0. A high proline content gives the chain rigidity and raises its resistance to proteolysis, so the peptide stays stable in the acidic gastric environment [1].

Directions of preclinical research

Historically the molecule was described by researchers at the University of Zagreb in the context of gastrointestinal mucosal protection [1]. Later work broadened the range of models.

  • Connective tissue. A review of musculoskeletal healing systematizes data on the peptide's effect on tendons, ligaments and muscle in animal models [3].
  • Angiogenesis and wounds. An alkali-burn model reports faster healing together with stimulation of proliferation, cell migration and vessel formation in vitro [2].
  • GI cytoprotection. A classic gastric mucosal injury model shows the protective profile of the compound [5].
  • Brain-gut axis. A review considers systemic effects of the peptide beyond the digestive tract [4].

Status and limits of interpretation

These results come mostly from cell cultures and laboratory animals. There is no approved protocol for use in humans, and no regulator has approved BPC-157 as a medicine. Data on human pharmacokinetics and long-term safety are limited. Any use therefore remains research only.

Quality control at Longeva

Longeva sends samples itself to independent third-party labs. Batches ship with a COA (certificate of analysis) that we publish in an open archive. For a specific lot the certificate becomes available once independent testing is complete.

See also

Buy the reagent: BPC-157. Reconstitution and literature dose ranges: BPC-157 dilution guide. The peptide is also available combined with TB-500: BPC-157 and TB-500, and standalone TB-500 on the TB-500 page.

Research material. Not a medicinal product.