Ipamorelin reference dosing
> Updated:
Human schedule
Ipamorelin is used as a subcutaneous injection; this is a generalized reference compiled from published studies and common protocols. Single doses are typically given 1–3 times per day, often 30–60 min before sleep.
This is a concise reference to regimens described for adults; it is not an individual prescription.
Ipamorelin dosing questions usually come down to injection frequency rather than a single dose: the table below shows how the starting dose is raised toward the main regimen.
| Period / condition | Dose | Escalation |
|---|---|---|
| Start (tolerance assessment) | 100 mcg subcutaneously, once daily | Starting dose |
| Gradual titration | +50 mcg every 1–2 weeks as needed | Increase if needed |
| Main regimen | 200–300 mcg per day, split across 1–3 injections | Maximum in this schedule |
Practical dosing and effect details
Ipamorelin is a pentapeptide that stimulates growth hormone (GH) release through ghrelin receptors. Raun and colleagues (European Journal of Endocrinology, 1998) showed it produces strong GH-releasing activity while not raising cortisol or ACTH beyond the level GHRH itself produces; that selectivity is what set it apart from older GH secretagogues, which trigger a broader hormonal cascade.
That selectivity ties directly to the schedule on this page: because the peptide does not touch off parallel hormonal spikes, protocols split the dose into several small injections per day (1 to 3) rather than one large dose. The starting dose is labeled a tolerance assessment: GH secretagogues can cause injection-site flushing, and a small first dose lets that reaction be checked before moving to the main regimen. Dosing before sleep lines up with the body's own nightly GH pulse.
This is reference information for planning a research protocol, not a medical recommendation and not instructions for self-administration.
This reference is research-use material. The information is not medical advice and is not intended for diagnosis, treatment or prevention of disease.