Semax: reference dosing schedule
> Updated:
Human schedule
Semax is used intranasally (0.1% drops or spray), with no injection or reconstitution. The following is a reference generalized from described studies and protocols.
This is a concise reference to regimens described for adults; it is not an individual prescription.
Semax nasal drops are usually searched for around one question, how many drops and how often, rather than the compound name itself; the table below answers that in concrete doses and course length.
| Period / condition | Dose | Escalation |
|---|---|---|
| Introductory regimen | 200–300 mcg per day (usually in the morning) | Starting dose |
| Standard regimen | 300–600 mcg per day, split into 1–2 doses | Increase if needed |
| Course | 10–30 days, then a 2–4 week break | Maximum in this schedule |
| Official label regimen (0.1% drops) | 600-900 mcg per day, 2-3 drops into each nostril 2-3 times a day | Course of 7-10 days (labels on apteka911, mozdocs, manufacturer "Peptogen") |
Practical dosing and effect details
In Manchenko and colleagues' study (Neuroscience and Behavioral Physiology, 2012), Semax was compared across different administration routes in rats: intranasal, intraperitoneal, and intramuscular. The nootropic and analgesic effect depended not only on dose but on how the peptide entered the body, meaning the route itself changed the outcome rather than being a minor technical detail.
That fits the logic of the intranasal schedule on this page: a short peptide with relatively fast metabolism is better sustained by frequent small doses (drops once or twice a day) than by an occasional large volume, which would mostly run off the mucosa rather than absorb.
That is also why the table above lists an 'introductory' regimen (200-300 mcg) separately from the higher manufacturer label regimen (600-900 mcg): these are two different sources for two different purposes, not conflicting numbers.
This is reference information from a preclinical study, not a medical recommendation and not instructions for self-administration.
This reference is research-use material. The information is not medical advice and is not intended for diagnosis, treatment or prevention of disease.