Semax: reference dosing schedule
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Calculate the Semax dose
Enter your dose and diluent volume for Semax — the calculator will do the rest.
Human dosing
Semax nasal drops are usually searched for around one question, how many drops and how often, rather than the compound name itself; the table below answers that in concrete doses and course length.
| Period / condition | Dose | Escalation |
|---|---|---|
| Introductory regimen | 200–300 mcg per day (usually in the morning) | Starting dose |
| Standard regimen | 300–600 mcg per day, split into 1–2 doses | Increase if needed |
| Course | 10–30 days, then a 2–4 week break | Maximum in this schedule |
| Official label regimen (0.1% drops) | 600-900 mcg per day, 2-3 drops into each nostril 2-3 times a day | Course of 7-10 days (labels on apteka911, mozdocs, manufacturer "Peptogen") |
Practical dosing and effect details
In Manchenko and colleagues' study (Neuroscience and Behavioral Physiology, 2012), Semax was compared across different administration routes in rats: intranasal, intraperitoneal, and intramuscular. The nootropic and analgesic effect depended not only on dose but on how the peptide entered the body, meaning the route itself changed the outcome rather than being a minor technical detail.
That fits the logic of the intranasal schedule on this page: a short peptide with relatively fast metabolism is better sustained by frequent small doses (drops once or twice a day) than by an occasional large volume, which would mostly run off the mucosa rather than absorb.
That is also why the table above lists an 'introductory' regimen (200-300 mcg) separately from the higher manufacturer label regimen (600-900 mcg): these are two different sources for two different purposes, not conflicting numbers.
This is reference information from a preclinical study, not a medical recommendation and not instructions for self-administration.
How to reconstitute
An example reconstitution for convenient dosing. The exact ratios depend on your vial. For research reference only — not medical guidance.
- 1Add the diluentUse bacteriostatic water. Example: 2 ml into a 5 mg vial.Semax5 mg+ 2 mlDiluent
- 2Get the concentrationExample: 5 mg in 2 ml =Semax2.5 mg/ml(2,500 mcg/ml)
- 3Work out the volume per doseFor example, for a 1.25 mg dose:1.25 mg = 0.5 ml= 50 u. (U-100)
This is only an example calculation. You can use a different diluent volume — plug your own numbers into the calculator. Open calculator →
Research protocols
Semax: reference regimens
Semax is used intranasally (0.1% drops or spray), with no injection or reconstitution. The following is a reference generalized from described studies and protocols.
More scientific background in the Semax monograph
Notes and safety
- • Semax is a research peptide. Human safety and efficacy data are limited.
- • The regimens shown are based on publications and research protocols, not clinical recommendations.
- • Individual reactions may vary. Published protocols typically start dosing at the lower end of the reported range.
- • Not recommended for use with chronic illness, pregnancy, or breastfeeding.
- • This information is for educational purposes and is not medical advice.
