Semax is a synthetic heptapeptide built from the ACTH(4–10) fragment with an added Pro-Gly-Pro tail. The research literature treats it as a nootropic and neuroprotective agent, with published work on BDNF and NGF expression, cholinergic and dopaminergic signaling, and neuronal survival in ischemia and oxidative-stress models. The bare fragment breaks down quickly in plasma, and the tail slows that enzymatic degradation. Because the molecule lacks the parent hormone's corticotropic activity, researchers can use it to isolate central-nervous-system effects on their own. It traces back to the Soviet neuropeptide research program that began in the 1980s and remains one of that program's best-known outputs.
One note on identity: beyond its use as a research reagent, Semax is also registered as a prescription drug in nasal-drop form in some countries. This Longeva listing is the lyophilized powder for laboratory and preclinical research, not that registered drug. Nothing on this page is medical advice or a human dosing instruction.
Research context
A study by Eremin et al. (Neurochemical Research, 2005, DOI 10.1007/s11064-005-8826-8) found that Semax activates dopaminergic and serotoninergic brain systems in rodents. That finding, alongside earlier observations on BDNF/NGF and cognitive models, is part of what the literature calls the molecule's nootropic profile. This is mechanistic background, not a promise of effect for any specific vial and not a human dosing protocol.
Sample format
Lyophilized powder in a vial. Store dry, cold, and protected from light per your lab's SOP. Log transport and storage conditions after receipt in your internal batch record. The reconstitution and titration scheme for a protocol is covered separately: see the Semax dosing protocol.
Verifying a batch by COA
- Find the LOT number on the vial and the outer packaging.
- Open the PDF for this substance in the COA archive.
- Check the substance name, methods (HPLC, identity), and result units.
- Log the receipt date and the check result in your internal record.
Related peptides in this category
More from the same Soviet neuropeptide research program and adjacent categories:
- Selank: an immunomodulatory peptide from the same research line, studied for a different profile (anxiety, immune regulation)
- DSIP (Delta sleep-inducing peptide): a peptide in the nerve / neuroregeneration category, studied in the context of sleep
Longeva supplies Semax as a research substance: lyophilized powder verified for identity and purity by HPLC at an independent third-party laboratory. Every batch ships with a certificate of analysis, published in the open archive at longeva.bio/en/coa and searchable by product name or lot number. A reagent for laboratory and preclinical research.
