Nicotinamide Riboside (NR)

Nicotinamide riboside (NR) is one of the most closely studied molecules in longevity science today: a direct feedstock for raising cellular NAD⁺, the coenzyme that fuels sirtuin activity and mitochondrial energy metabolism and that declines with age. It is the outlier in this catalogue — most items here are synthetic peptides with limited or purely preclinical evidence, while NR is an established nutrient with GRAS status in the US and novel-food authorisation (as the chloride salt) in the EU since 2020.

The scientific interest in NR comes from its dedicated entry route: nicotinamide riboside kinases (NRK1/NRK2) phosphorylate it to NMN, bypassing the classical Preiss-Handler pathway. Those genes were only described in 2004 — a vitamin known for decades was assigned its own metabolic route in retrospect.

An honest note on the evidence: in human studies NR reliably and reproducibly raises NAD⁺ in blood and muscle, yet most randomised trials did NOT show improvements in insulin sensitivity, mitochondrial respiration or body composition. The gap between the biomarker and the functional outcome is this compound's central open question. A detailed review with primary-source citations is in the linked wiki monograph.

This item is not currently available to order. You can register interest via the notification form on this page — we will let you know when a batch with a certificate of analysis reaches the warehouse.

Store dry, protected from light and moisture; NR is hygroscopic and less stable than nicotinamide, so freezing is recommended for long-term storage.