Humanin: dosing in studies (preclinical)
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Human schedule
Controlled data on this compound are limited. The regimens below were gathered from public sources online (studies and protocols) and are given as a reference, not a usage plan.
Humanin is described in sources as a subcutaneous (SC) injection; the HNG (S14G) analog is markedly more potent and so is used in smaller amounts. The figures are a generalized reference from preclinical work and community protocols, with no approved clinical dosing.
This is a concise reference to regimens described for adults; it is not an individual prescription.
Humanin dosing and its more potent HNG (S14G) analog differ by roughly an order of magnitude, so the humanin dosing schedule below lists the native form and the synthetic analog separately rather than as a single figure.
| Period / condition | Dose | Escalation |
|---|---|---|
| Native humanin (SC) | 1–3 mg, 2–3x per week | Starting dose |
| HNG / S14G analog (SC) | 100–500 mcg, 2–3x per week | More potent form, lower dose |
| Cycle length | 4–8 weeks, then off | Maximum in this schedule |
Practical dosing and effect details
Native humanin and its HNG (S14G) analog act on the same signaling pathway, but a single point substitution of serine for glycine at position 14, hence the abbreviation S14G, raises the analog's affinity for the receptor complex. That is why the schedule here doses HNG at roughly a tenth of the native peptide's amount (100-500 mcg versus 1-3 mg) at the same frequency, 2-3 times a week: higher affinity means less material is needed to produce the same signal. Sources administer both forms subcutaneously in short cycles (4-8 weeks) with a break, rather than continuously: controlled human clinical trials of humanin are scarce, and the published regimens lean mainly on preclinical work and community research protocols rather than an approved clinical schedule. This is reference information for planning a research protocol, not a medical recommendation and not instructions for self-administration.
This reference is research-use material. The information is not medical advice and is not intended for diagnosis, treatment or prevention of disease.