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Humanin — a 24-aa mitochondrial-derived peptide (MDP) studied for cytoprotection in metabolic and aging research. Lyophilized, HPLC ≥98%. Research use only (RUO).
Size: 10 mg
No published analyses yet.
Titration schedule · reference
The information below is provided from public sources for reference only. It is not advice or instructions for use; products are intended for laboratory research only and not for human consumption.
| Period / condition | Dose | Escalation |
|---|---|---|
| Native humanin (SC) | 1–3 mg, 2–3x per week | Starting dose |
| HNG / S14G analog (SC) | 100–500 mcg, 2–3x per week | More potent form, lower dose |
| Cycle length | 4–8 weeks, then off | Maximum in this schedule |
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Humanin is a 24-amino-acid mitochondrial-derived peptide (MDP) encoded within the 16S rRNA region of mitochondrial DNA. It holds a landmark position in ageing and mitochondrial-biology research as the first identified member of the MDP class — peptides that carry signals from mitochondria to the nucleus.
In preclinical research humanin is studied as a cytoprotective, anti-apoptotic molecule: it binds the pro-apoptotic protein Bax, interacts with IGFBP-3 and activates pro-survival cascades, and in metabolic models it influences insulin sensitivity. Endogenous humanin declines with age, making it an intriguing subject for gerontological and neuroprotective research.
This is a frontier compound, rarely offered on the market, for laboratories working at the interface of mitochondrial and ageing biology. Supplied as a lyophilised powder for research.
