Humanin
Humanin
About
Humanin is a 24-amino-acid mitochondrial-derived peptide (MDP) encoded within the 16S rRNA region of mitochondrial DNA. It holds a landmark position in ageing and mitochondrial-biology research as the first identified member of the MDP class — peptides that carry signals from mitochondria to the nucleus.
In preclinical research humanin is studied as a cytoprotective, anti-apoptotic molecule: it binds the pro-apoptotic protein Bax, interacts with IGFBP-3 and activates pro-survival cascades, and in metabolic models it influences insulin sensitivity. Endogenous humanin declines with age, making it an intriguing subject for gerontological and neuroprotective research.
This is a frontier compound, rarely offered on the market, for laboratories working at the interface of mitochondrial and ageing biology. Supplied as a lyophilised powder for research.
Specifications
Dosing
There is no established human dosing protocol for humanin. This reference collects only preclinical regimens studied in animals (mice): HNG 4 mg/kg intraperitoneally twice weekly (Yen 2020) and native humanin 0.7–2 mg/kg/day intraperitoneally (Hoang 2010). Every value is tied to a published DOI-cited source; there are no human equivalents.
Full dosing guideTitration schedule · reference
