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Nicotinamide riboside (NR) — the riboside form of vitamin B3 and a direct NAD⁺ precursor. Unlike the rest of this catalogue it is not a peptide but an orally bioavailable small molecule with an unusually large clinical dataset. HPLC purity ≥98%.
Size: 1 g
No published analyses yet.
Titration schedule · reference
The information below is provided from public sources for reference only. It is not advice or instructions for use; products are intended for laboratory research only and not for human consumption.
| Period / condition | Dose | Escalation |
|---|---|---|
| Start | 250-300 mg per day | Starting dose |
| Typical regimen | 500-600 mg per day (once or split into 2) | Increase if needed |
| High-dose research | 1000-2000 mg per day | Maximum in this schedule |
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Nicotinamide riboside (NR) is one of the most closely studied molecules in longevity science today: a direct feedstock for raising cellular NAD⁺, the coenzyme that fuels sirtuin activity and mitochondrial energy metabolism and that declines with age. It is the outlier in this catalogue — most items here are synthetic peptides with limited or purely preclinical evidence, while NR is an established nutrient with GRAS status in the US and novel-food authorisation (as the chloride salt) in the EU since 2020.
The scientific interest in NR comes from its dedicated entry route: nicotinamide riboside kinases (NRK1/NRK2) phosphorylate it to NMN, bypassing the classical Preiss-Handler pathway. Those genes were only described in 2004 — a vitamin known for decades was assigned its own metabolic route in retrospect.
An honest note on the evidence: in human studies NR reliably and reproducibly raises NAD⁺ in blood and muscle, yet most randomised trials did NOT show improvements in insulin sensitivity, mitochondrial respiration or body composition. The gap between the biomarker and the functional outcome is this compound's central open question. A detailed review with primary-source citations is in the linked wiki monograph.
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Store dry, protected from light and moisture; NR is hygroscopic and less stable than nicotinamide, so freezing is recommended for long-term storage.
